An unidentified man apparently died in the crash on South Church Street, WFMZ reports.
The road was closed between Chestnut Street and Bridge Street sometime around 6 p.m., Whitehall Township police said on Twitter.
Police are urging motorists to steer clear of the area.
This story is developing. Check back to Daily Voice for updates.
Click here to follow Daily Voice Lehigh and receive free news updates.